The Barbour Lab at
Virginia Commonwealth University

The Barbour Lab aims to uncover the multiscale mechanisms by which altered neuronal circuitry disrupts memory in the early, prodromal stages of Alzheimer' disease (AD). Memory loss is a devastating and hallmark symptom of AD, yet the cellular, circuit, and network processes that drive this dysfunction are poorly understood. The early, prodromal stages of AD occur prior to widespread neuronal loss and are a critical therapeutic window in which strategies to reinstate network function may be most effective. Through the integration of brain-wide mapping, circuit interrogation, molecular profiling, and drug repurposing, we utilize an innovative and comprehensive framework to determine how memory networks are compromised and how they might be restored during this pivotal stage of AD.